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https://www.creative-diagnostics.com/Co-immunoprecipitation-Co-IP-MS.htm

Science and Technology

Co-immunoprecipitation (Co-IP) is one of the most commonly used methods for determining protein-protein interactions. It relies on the ability of an antibody to stably and specifically bind complexes containing a bait protein. The antibody provides a means of immobilizing these complexes on a solid matrix. In this way, it is possible to detect the unknown members of proteins or ligands that are bound to the specific protein in natural condition.